Based on the medium and long-term development targets of nuclear power in China, the mainstream reactor types M310 and AP1000 are taken as research object, the several scenarios of nuclear fuel cycle of PWR are assumed before 2050 and their feasibilities are analyzed based on the fact that the fast reactor is planning to be built in China. The resource requirements for Uranium and Plutonium in the hypothetical scenarios of nuclear fuel cycle are carried out by using DESAE program. The results could provide a data reference for the China's nuclear energy development strategy. The comparison and analysis of calculation results show that the amount of natural Uranium saving mainly depends on the scale of PWR using MOX fuel.