Through studying on Zoophycos from three Late Paleozoic sections (the Dahekou Devonian section, the Ercengpuo Carboniferous section, and the Dongpan Permian section) and summarizing the previous related literatures on the Late Paleozoic Zoophycos in South China, the Zoophycos from these regions represent the complex spreiten with well-preserved major and minor lamellae, and consist of marginal tube and cylindrical tunnel. A systematic investigation of morphology and palaeoenvironment of Zoophycos is carried out. The study indicates that (1) both the spiral-like and tougue-like Zoophycos are identified. (2) Zoophycos are mainly distributed in the Early-Middle Devonian (Emsian-Eifelian), Mississippian (Visean), and Guadalupian (Wordian); and mainly occur in the southeast of Guizhou Province, central-southern of Hunan Province, and northeastern of Guangxi Province, and are abundant in a condition with a lower energy and soft substrate from shoreface to subtidal shelf. It seems that the spatiotemporal distributions of the Late Paleozoic Zoophycos in South China are coupled with the Late Paleozoic evolution of atmosphere oxygen (17%—24%), climate and temperature (20—25℃), seawater geochemical compositions (calcite seas, Mg/Ca<2), and mass biological extinction events.