This paper briefly introduced the necessary steps of tailoring during the application of systems engineering. There are two levels of tailoring:organization-level tailoring and project-level tailoring. A practical tailoring strategy is proposed, cutting unnecessary processes/activities and tasks at first, then adjusting or calibrating in accordance with precise needs. On the basis of references of mature methods, some mistakes and traps are listed to be avoided. At last, in the light of tailoring strategies, a series of domain cases are analyzed from the view of systems engineering application. These research results could be reference for the proper application of systems engineering in the new domains.
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