This paper analyzes the principle and the system of security informatics, for the construction of the safety information science, with 4 kinds of the security information. According to the security information, 6 kinds of scientific principles of safety informatics are identified:the security of human body information principle, the safety principle, the material information security environment, the principle of information security management information, the social security information principle and the principle of information security system principle, in 30 levels. The connotation of each principle is discussed. A honeycomb structure of the principles of safety informatics is constructed to reveal the relation and the development of the principles of safety information. It is shown that with the system safety and security as the background, a safe information under a new system of safety science principle can be built, enriched and improved.
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