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Cytotoxic activity of secondary metabolites from co-culture of Eurotium cristatum with Staphylococcus aureus

  • YANG Juanjuan ,
  • ZOU Xianwei ,
  • HUANG Yun ,
  • LI Qian ,
  • CHEN Benke ,
  • TANG Jintian
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  • 1. Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin;College of Life Sciences, Tarim University, Alar 843300, China;
    2. Key Laboratory of Particle & Radiation Imaging, Ministry of Education;Department of Engineering Physics, Tsinghua University, Beijing 100084, China

Received date: 2016-01-14

  Revised date: 2016-02-26

  Online published: 2016-06-13

Abstract

To evaluate the cytotoxic activity of secondary metabolites from co-culture of Eurotium cristatum with Staphylococcus aureus, seven known compounds, including echinulin(1), cristatumin F(2), neoechinulin A(3), preechinulin (4), flvoglaucin (5), tetrahydroauroglaucine (6), and epiheveadride (7) are isolated from the solid culture of the co-culture of Eurotiumcristatum with Staphylococcus aureus. The structures are checked on the basis of spectroscopic analysis NMR experiments and by mass spectrometric measurements. These metabolites are evaluated in vitro for cytotoxicity activities against four tumor cell lines such as A549, MCF-7, Bel-7402, and Colo205. Compounds 3, 5 and 7 are found to show moderate cytotoxicity against the Bel-7402 cancer cell line.

Cite this article

YANG Juanjuan , ZOU Xianwei , HUANG Yun , LI Qian , CHEN Benke , TANG Jintian . Cytotoxic activity of secondary metabolites from co-culture of Eurotium cristatum with Staphylococcus aureus[J]. Science & Technology Review, 2016 , 34(9) : 96 -101 . DOI: 10.3981/j.issn.1000-7857.2016.09.012

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