The effect of the Uygur medicine Hyssopus officinalis L. total flavonoids on pathological changes in the lung tissue of asthmatic rats is observed and the total number of cells and the percentage of lymphocytes (Ly), eosinophils (Eos), neutrophils (Neu) in BALF, the level of TGF-β1 in BALF and the lung tissue are studied for the mechanism of its treatment of asthma. The rats were randomly divided into the normal control group, the asthma model group, the aminophylline treatment group, the Hyssopus total flavonoids groups of high, medium and low dose treatments. They were sensitized with OVA, Al(OH)3 and DPT vaccine and then were challenged with the inhalation of aerosolized OVA solution for preparation of the asthma model. The level of the lung tissue and BALF TGF-β1 were determined with ELISA, the total number of cells and the percentage of Ly, Eos, Neu in BALF were determined by light microscope. The results show that as compared with the asthma model group, the level of TGF-β1, the total number of cells and the percentage of Ly, Eos, Neu in BALF and the level of the lung tissue TGF-β1 were significantly lower in those of treated groups (P<0.05); among different dose treatment groups, the level of TGF-β1, the total number of cells and the percentage of Ly, Eos, Neu in BALF and the level of the lung tissue TGF-β1 were significantly reduced (P<0.05) with a dose-dependent trend in alleviating the airway inflammation of the asthma., Hyssopus officinalis L. total flavonoids may inhibit the secretion of TGF-β1, Ly, Eos, Neu, reducing the airway inflammation of the asthma.
EKIM Mahsum, ROZI Nurjan, YUSUP Abdiryim
. Effect of Uighur Medicine Hyssopus officinalis L. Total Flavonoids on Airway Inflammation in Ovalbumin-induced Asthmatic Rats[J]. Science & Technology Review, 2013
, 31(36)
: 71
-75
.
DOI: 10.3981/j.issn.1000-7857.2013.36.012
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