探讨胰腺癌患者血清中CEA,CA199,IL-6和MCP-1的表达及临床意义。检测118例胰腺癌患者,107例慢性胰腺炎患者和113例健康人群血清中CEA,CA199,IL-6和MCP-1的含量,评价其单独检测和联合检测对于胰腺癌的诊断价值。与正常对照组相比较,慢性胰腺炎组的CA199和MCP-1有统计学差异,胰腺癌组的CEA,CA199,IL-6和MCP-1均显著升高。与慢性胰腺炎组相比较,胰腺癌组的CA199和IL-6均显著升高。当这4种指标单独区分慢性胰腺炎组和胰腺癌组时,诊断能力最好的指标CA199,其诊断灵敏性和特异性分别为72.30%和74.90%。细胞因子中IL-6的诊断灵敏性较高,为85.40%,而其特异性较低,为57.50%。 CA199和IL-6联合诊断慢性胰腺炎和胰腺癌时,其诊断价值高于任一单独指标检测,其灵敏性和特异性分别为87.30%和90.30%。单独检测灵敏性和特异性诊断价值有限,而联合检测可有效提高其诊断水平,具有一定的辅助诊断价值。

This paper studies the CEA, CA199, IL-6 and MCP-1 expressions and their clinical significance in the serum of patients with pancreatic cancer. The concentrations of IL-6, MCP-1, CEA and CA199 were detected in 118 pancreatic cancer patients, 107 chronic pancreatitis patients and 113 healthy people. In addition, their individual and joint diagnostic values for pancreatic cancer were also evaluated. Compared with the normal control group, the CA199 and MCP-1 of the chronic pancreatitis group show significant difference. The CEA, CA199, IL-6 and MCP-1 of the pancreatic cancer group show significant increase. Compared with the chronic pancreatitis group, the CA199 and IL-6 of the pancreatic cancer group show significant increase. When the four indicators were used separately to differentiate the chronic pancreatitis group and pancreatic cancer group, the best diagnostic value is shown by the CA199. The diagnostic sensitivity and specificity are 72.30% and 74.90%. The IL-6 shows a sensitivity of 85.40% and a specificity of 57.50%. The joint diagnostic values of CA199 and IL-6 for differentiating chronic pancreatitis group and pancreatic cancer group are higher than any other indicator. The sensitivity and the specificity are 87.30% and 90.30%. The indicator shows a limited diagnostic value for clinical diagnosis. The joint indicators show a better diagnostic value than the individual indicator. It is a useful diagnostic method for helping the diagnosis of pancreatic cancer.