专题论文

癫痫的发病机制研究进展

  • 杨华俊 ,
  • 郭安臣 ,
  • 王群
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  • 1. 首都医科大学附属北京天坛医院神经病学中心, 北京 100050;
    2. 北京脑重大疾病研究院, 北京 100069;
    3. 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心, 北京 100050
杨华俊,博士研究生,研究方向为癫痫基础与临床,电子信箱:doctor_yanghuajun@126.com

收稿日期: 2016-12-28

  修回日期: 2017-02-13

  网络出版日期: 2017-02-28

基金资助

国家自然科学基金项目(81271312);首都卫生发展科研专项(首发2016-1-2011);北京市医院管理局临床新技术创新项目(XMLX201401)

Advances in pathogenesis of epilepsy

  • YANG Huajun ,
  • GUO Anchen ,
  • WANG Qun
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  • 1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
    2. Beijing Institute for Brain Disorders, Beijing 100069, China;
    3. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

Received date: 2016-12-28

  Revised date: 2017-02-13

  Online published: 2017-02-28

摘要

癫痫是神经系统的常见疾病之一,其发病机制十分复杂,目前尚未完全阐明。近年来,关于癫痫发病机制的研究表明,癫痫的发生与离子通道、神经递质、突触连接、神经血管单元、神经胶质细胞等均存在密切联系。为深入理解癫痫发病机制,为诊断、预防与治疗癫痫提供必要的理论依据,本文从离子通道、神经突触传递与连接、神经血管单元完整性、神经胶质细胞4个方面对癫痫发生机制的研究进展做一综述。

本文引用格式

杨华俊 , 郭安臣 , 王群 . 癫痫的发病机制研究进展[J]. 科技导报, 2017 , 35(4) : 54 -59 . DOI: 10.3981/j.issn.1000-7857.2017.04.009

Abstract

The epilepsy is one of the most common diseases of the nervous system, and its pathogenesis is very complex. In recent years, studies of the pathogenesis of the epilepsy have shown that the occurrence of the epilepsy is closely related to the ion channels, the neurotransmitters, the synaptic connections, the neurovascular units and the glial cells. This review focuses on the pathogenesis of the epilepsy and the theoretical basis for the diagnosis, the prevention and the treatment of the epilepsy.

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