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环境污染物的抗雌激素效应及机制研究进展

  • 汝少国 ,
  • 郭琳琳
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  • 中国海洋大学海洋生命学院, 青岛266003
汝少国, 教授, 研究方向为生态毒理学、污染生态学等, 电子信箱:rusg@ouc.edu.cn

收稿日期: 2014-12-23

  修回日期: 2015-02-12

  网络出版日期: 2015-05-15

基金资助

国家自然科学基金项目(31170322)

Research progress on antiestrogen effects and mechanism of environmental pollutants

  • RU Shaoguo ,
  • GUO Linlin
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  • College of Marine Life Science, Ocean University of China, Qingdao 266003, China

Received date: 2014-12-23

  Revised date: 2015-02-12

  Online published: 2015-05-15

摘要

列举了10 余种具有抗雌激素效应的环境污染物, 从拮抗E2水平、拮抗E2功能、拮抗雌性性征3 个方面阐释了这些物质的抗雌激素效应, 并进一步论述了其在E2合成、运输、受体结合及代谢等方面发挥抗雌激素效应的机制。展望了环境污染物的抗雌激素效应及相关机制的研究方向。

本文引用格式

汝少国 , 郭琳琳 . 环境污染物的抗雌激素效应及机制研究进展[J]. 科技导报, 2015 , 33(9) : 93 -99 . DOI: 10.3981/j.issn.1000-7857.2015.09.016

Abstract

This paper identifies ten kinds of environmental pollutants with antiestrogen effects, focusing on their antagonist effects on the E2 levels, the E2 function and the female characters. Furthermore, the mechanism of antiestrogen effects in the synthesis, the transportation, the receptor binding and the metabolism of E2 is discussed. Finally, based on the above analyses, the future researches of the antiestrogen effects and the underlying mechanism of environmental pollutants are suggested.

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