以羟丙基-β-环糊精、甲基-β-环糊精为手性固定相，氧化多壁碳纳米管为拆分辅助吸附添加剂，采用薄层色谱法拆分了盐酸普萘洛尔对映体。优化得到了最佳展开剂条件，并对展开剂中是否添加冰醋酸进行了比较。当以羟丙基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/异丁醇（体积比为9:1）混合溶剂中添加体积分数为2%的冰醋酸。当以甲基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/正丁醇（体积比为1：1）混合溶剂中添加体积分数为2%的冰醋酸。
This paper evaluates the hydroxypropyl-β-cyclodextrin or methyl-β-cyclodextrin-based chiral stationary phase, with oxidized multi-walled carbon nanotubes as additional adsorbing materials, for the chiral separation of propranolol hydrochloride enantiomers. The compositions of the developing solvent (acetonitrile/various alcohols), with/without acetic acid, are optimized. The optimal solvent system of acetonitrile/iso-butanol 9/1 (V/V) containing 2% acetic acid (in volume) for hydroxypropyl-β-cyclodextrin/ oxidized multi-walled carbon nanotubes impregnated thin-layer chromatography, and the optimal solvent system of acetonitrile/n-butanol 1/1 (V/V) containing 2% acetic acid (in volume) for methyl-β-cyclodextrin/oxidized multi-walled carbon nanotubes impregnated thinlayer chromatography are obtained.
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